Xolair
Anti-IgE therapy for chronic urticaria that no longer answers antihistamines.
Xolair (omalizumab) binds free IgE and lowers the mast-cell reactivity behind chronic spontaneous urticaria — daily hives, deep swelling and relentless itch. It is the established next step when high-dose antihistamines fail to hold symptoms.
- Injection
- Route
- 4 weekly
- Interval
- 2–8 wks
- First results
- Free IgE
- Target
- Urticaria activity scoring
- Trigger and drug review
- Monthly injection
- Steroid-sparing plan
Diagnosed first, treated second.
Because urticaria is often mistaken for allergy, treatment begins with a proper differential: thyroid function, autoimmune markers, physical triggers and medication review. Dosing is then monthly, with a symptom diary quantifying response rather than memory.
- 01Urticaria activity scoring
- 02Trigger and drug review
- 03Monthly injection
- 04Steroid-sparing plan
- 05Structured taper
- Hives persisting beyond six weeks
- No control on high-dose antihistamines
- Recurrent angioedema
- Repeated courses of oral steroids
- Significant sleep or quality-of-life impact
How the treatment works
A sequence, not a single appointment — each step informs the next.
- 01
Diagnosis
Urticaria activity scoring, trigger review and bloodwork to exclude mimics and drivers.
- 02
Antihistamine optimisation
Confirming the ceiling of conventional therapy before biologics are introduced.
- 03
Monthly dosing
Subcutaneous injection in clinic every four weeks, with observation after early doses.
- 04
Review
Activity scores at each visit; dose interval and duration adjusted on symptom control.
Results measured, not promised.
What to expect
- 01Fewer hive episodes within the first month
- 02Marked reduction in itch and night waking
- 03Less angioedema and facial swelling
- 04Lower reliance on oral steroids
- 05Many patients reach complete control
Begin with a diagnosis,
not a guess.
Share a few details and the clinic will reply with available consultation times for xolair — one-to-one with Dr. Arely.
- Response
- Within 24 hours
- Consultation
- One-to-one, 45 min
- Assessment
- Trichoscopy included
- Location
- Dr. Arely Clinic
Frequently asked
Usually not. Most cases are autoimmune or spontaneous, which is why avoidance diets rarely resolve them.
A minimum of six months is typical, then a planned taper once control is stable.
Some patients relapse and resume treatment; many remain in remission after a supervised taper.
Discomfort is brief and comparable to any subcutaneous injection.